Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents

Current drugs against human African trypanosomiasis (HAT) suffer from several serious drawbacks. The search for novel, effective, brain permeable, safe, and inexpensive antitrypanosomal compounds is therefore an urgent need. We have recently reported that the 4-aminoquinoline derivative huprine Y, d...

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Detalles Bibliográficos
Autores principales: Sola, Irene, Artigas, Albert, Taylor, Martin C., Pérez-Areales, F. Javier, Viayna, Elisabet, Clos, M. Victòria, Pérez, Belén, Wright, Colin W., Kelly, John M., Muñoz-Torrero, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080452/
https://www.ncbi.nlm.nih.gov/pubmed/27591008
http://dx.doi.org/10.1016/j.bmc.2016.08.036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080452/
https://www.ncbi.nlm.nih.gov/pubmed/27591008
http://dx.doi.org/10.1016/j.bmc.2016.08.036

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