Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling

Type I interferon (IFN-I) mediated innate immune response controls virus infections by inducing the expression of interferon stimulated genes (ISGs). Although ubiquitination plays key roles in immune signaling regulation, a human genome-wide understanding of the role of E3 ubiquitin ligases in inter...

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Detalles Bibliográficos
Autores principales: Nair, Sajith, Bist, Pradeep, Dikshit, Neha, Krishnan, Manoj N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080589/
https://www.ncbi.nlm.nih.gov/pubmed/27782195
http://dx.doi.org/10.1038/srep36179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080589/
https://www.ncbi.nlm.nih.gov/pubmed/27782195
http://dx.doi.org/10.1038/srep36179

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