Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model

The aim of this tutorial is to introduce the fundamental concepts of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their practical implementation in a typical PBPK model building workflow. To illustrate basic steps in PBPK model building, a PBPK mod...

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Detalles Bibliográficos
Autores principales: Kuepfer, L, Niederalt, C, Wendl, T, Schlender, J‐F, Willmann, S, Lippert, J, Block, M, Eissing, T, Teutonico, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Tutorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080648/
https://www.ncbi.nlm.nih.gov/pubmed/27653238
http://dx.doi.org/10.1002/psp4.12134
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author Kuepfer, L
Niederalt, C
Wendl, T
Schlender, J‐F
Willmann, S
Lippert, J
Block, M
Eissing, T
Teutonico, D
author_facet Kuepfer, L
Niederalt, C
Wendl, T
Schlender, J‐F
Willmann, S
Lippert, J
Block, M
Eissing, T
Teutonico, D
author_sort Kuepfer, L
collection PubMed
description The aim of this tutorial is to introduce the fundamental concepts of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their practical implementation in a typical PBPK model building workflow. To illustrate basic steps in PBPK model building, a PBPK model for ciprofloxacin will be constructed and coupled to a pharmacodynamic model to simulate the antibacterial activity of ciprofloxacin treatment.
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spelling pubmed-50806482016-10-31 Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model Kuepfer, L Niederalt, C Wendl, T Schlender, J‐F Willmann, S Lippert, J Block, M Eissing, T Teutonico, D CPT Pharmacometrics Syst Pharmacol Tutorial The aim of this tutorial is to introduce the fundamental concepts of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their practical implementation in a typical PBPK model building workflow. To illustrate basic steps in PBPK model building, a PBPK model for ciprofloxacin will be constructed and coupled to a pharmacodynamic model to simulate the antibacterial activity of ciprofloxacin treatment. John Wiley and Sons Inc. 2016-10-19 2016-10 /pmc/articles/PMC5080648/ /pubmed/27653238 http://dx.doi.org/10.1002/psp4.12134 Text en © 2016 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Tutorial
Kuepfer, L
Niederalt, C
Wendl, T
Schlender, J‐F
Willmann, S
Lippert, J
Block, M
Eissing, T
Teutonico, D
Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model
title Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model
title_full Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model
title_fullStr Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model
title_full_unstemmed Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model
title_short Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model
title_sort applied concepts in pbpk modeling: how to build a pbpk/pd model
topic Tutorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080648/
https://www.ncbi.nlm.nih.gov/pubmed/27653238
http://dx.doi.org/10.1002/psp4.12134
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