Systematic Analysis of Quantitative Logic Model Ensembles Predicts Drug Combination Effects on Cell Signaling Networks

A major challenge in developing anticancer therapies is determining the efficacies of drugs and their combinations in physiologically relevant microenvironments. We describe here our application of “constrained fuzzy logic” (CFL) ensemble modeling of the intracellular signaling network for predictin...

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Detalles Bibliográficos
Autores principales: Morris, MK, Clarke, DC, Osimiri, LC, Lauffenburger, DA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080650/
https://www.ncbi.nlm.nih.gov/pubmed/27567007
http://dx.doi.org/10.1002/psp4.12104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080650/
https://www.ncbi.nlm.nih.gov/pubmed/27567007
http://dx.doi.org/10.1002/psp4.12104

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