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Predicting Effects of Tropomyosin Mutations on Cardiac Muscle Contraction through Myofilament Modeling
Point mutations to the human gene TPM1 have been implicated in the development of both hypertrophic and dilated cardiomyopathies. Such observations have led to studies investigating the link between single residue changes and the biophysical behavior of the tropomyosin molecule. However, the degree...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081029/ https://www.ncbi.nlm.nih.gov/pubmed/27833562 http://dx.doi.org/10.3389/fphys.2016.00473 |