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Role of Sialidase in Long-Term Potentiation at Mossy Fiber-CA3 Synapses and Hippocampus-Dependent Spatial Memory

Sialic acid bound to glycans in glycolipids and glycoproteins is essential for synaptic plasticity and memory. Sialidase (EC 3.2.1.18), which has 4 isozymes including Neu1, Neu2, Neu3 and Neu4, regulates the sialylation level of glycans by removing sialic acid from sialylglycoconjugate. In the prese...

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Detalles Bibliográficos
Autores principales: Minami, Akira, Saito, Masakazu, Mamada, Shou, Ieno, Daisuke, Hikita, Tomoya, Takahashi, Tadanobu, Otsubo, Tadamune, Ikeda, Kiyoshi, Suzuki, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081204/
https://www.ncbi.nlm.nih.gov/pubmed/27783694
http://dx.doi.org/10.1371/journal.pone.0165257