Fatty acid analogue N-arachidonoyl taurine restores function of I(Ks) channels with diverse long QT mutations

About 300 loss-of-function mutations in the I(Ks) channel have been identified in patients with Long QT syndrome and cardiac arrhythmia. How specific mutations cause arrhythmia is largely unknown and there are no approved I(Ks) channel activators for treatment of these arrhythmias. We find that seve...

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Detalles Bibliográficos
Autores principales: Liin, Sara I, Larsson, Johan E, Barro-Soria, Rene, Bentzen, Bo Hjorth, Larsson, H Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081249/
https://www.ncbi.nlm.nih.gov/pubmed/27690226
http://dx.doi.org/10.7554/eLife.20272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081249/
https://www.ncbi.nlm.nih.gov/pubmed/27690226
http://dx.doi.org/10.7554/eLife.20272

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