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Fatty acid analogue N-arachidonoyl taurine restores function of I(Ks) channels with diverse long QT mutations
About 300 loss-of-function mutations in the I(Ks) channel have been identified in patients with Long QT syndrome and cardiac arrhythmia. How specific mutations cause arrhythmia is largely unknown and there are no approved I(Ks) channel activators for treatment of these arrhythmias. We find that seve...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081249/ https://www.ncbi.nlm.nih.gov/pubmed/27690226 http://dx.doi.org/10.7554/eLife.20272 |