Increased Motor-Impairing Effects of the Neuroactive Steroid Pregnanolone in Mice with Targeted Inactivation of the GABA(A) Receptor γ2 Subunit in the Cerebellum

Endogenous neurosteroids and neuroactive steroids have potent and widespread actions on the brain via inhibitory GABA(A) receptors. In recombinant receptors and genetic mouse models their actions depend on the α, β, and δ subunits of the receptor, especially on those that form extrasynaptic GABA(A)...

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Detalles Bibliográficos
Autores principales: Leppä, Elli, Linden, Anni-Maija, Aller, Maria I., Wulff, Peer, Vekovischeva, Olga, Luscher, Bernhard, Lüddens, Hartmut, Wisden, William, Korpi, Esa R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081378/
https://www.ncbi.nlm.nih.gov/pubmed/27833556
http://dx.doi.org/10.3389/fphar.2016.00403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081378/
https://www.ncbi.nlm.nih.gov/pubmed/27833556
http://dx.doi.org/10.3389/fphar.2016.00403

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