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15-Deoxy-Δ(12,14)-Prostaglandin J(2) Modifies Components of the Proteasome and Inhibits Inflammatory Responses in Human Endothelial Cells
15-Deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)) is an electrophilic lipid mediator derived from PGD(2) with potent anti-inflammatory effects. These are likely to be due to the covalent modification of cellular proteins, via a reactive α,β-unsaturated carbonyl group in its cyclopentenone ring. This...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081389/ https://www.ncbi.nlm.nih.gov/pubmed/27833612 http://dx.doi.org/10.3389/fimmu.2016.00459 |