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15-Deoxy-Δ(12,14)-Prostaglandin J(2) Modifies Components of the Proteasome and Inhibits Inflammatory Responses in Human Endothelial Cells

15-Deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)) is an electrophilic lipid mediator derived from PGD(2) with potent anti-inflammatory effects. These are likely to be due to the covalent modification of cellular proteins, via a reactive α,β-unsaturated carbonyl group in its cyclopentenone ring. This...

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Detalles Bibliográficos
Autores principales:	Marcone, Simone, Evans, Paul, Fitzgerald, Desmond J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081389/ https://www.ncbi.nlm.nih.gov/pubmed/27833612 http://dx.doi.org/10.3389/fimmu.2016.00459

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