LRRK2 Inhibits FAK Activity by Promoting FERM-mediated Autoinhibition of FAK and Recruiting the Tyrosine Phosphatase, SHP-2

Mutation of leucine-rich repeat kinase 2 (LRRK2) causes an autosomal dominant and late-onset familial Parkinson's disease (PD). Recently, we reported that LRRK2 directly binds to and phosphorylates the threonine 474 (T474)-containing Thr-X-Arg(Lys) (TXR) motif of focal adhesion kinase (FAK), th...

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Detalles Bibliográficos
Autores principales: Choi, Insup, Byun, Ji-won, Park, Sang Myun, Jou, Ilo, Joe, Eun-Hye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Brain and Neural Science 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081473/
https://www.ncbi.nlm.nih.gov/pubmed/27790061
http://dx.doi.org/10.5607/en.2016.25.5.269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081473/
https://www.ncbi.nlm.nih.gov/pubmed/27790061
http://dx.doi.org/10.5607/en.2016.25.5.269

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