Cargando…

Serelaxin Elicits Bronchodilation and Enhances β-Adrenoceptor-Mediated Airway Relaxation

Treatment with β-adrenoceptor agonists does not fully overcome the symptoms associated with severe asthma. Serelaxin elicits potent uterine and vascular relaxation via its cognate receptor, RXFP1, and nitric oxide (NO) signaling, and is being clinically evaluated for the treatment of acute heart fai...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lam, Maggie, Royce, Simon G., Donovan, Chantal, Jelinic, Maria, Parry, Laura J., Samuel, Chrishan S., Bourke, Jane E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081476/ https://www.ncbi.nlm.nih.gov/pubmed/27833558 http://dx.doi.org/10.3389/fphar.2016.00406

Ejemplares similares

Influenza A virus infection and cigarette smoke impair bronchodilator responsiveness to β-adrenoceptor agonists in mouse lung
por: Donovan, Chantal, et al.
Publicado: (2016)

Rosiglitazone is a superior bronchodilator compared to chloroquine and β-adrenoceptor agonists in mouse lung slices
por: Donovan, Chantal, et al.
Publicado: (2014)

β-Adrenoceptor-mediated Relaxation of Urinary Bladder Muscle in β(2)-Adrenoceptor Knockout Mice
por: Propping, Stefan, et al.
Publicado: (2016)

A New Pathway to Airway Relaxation: Targeting the “Other” Cyclase in Asthma
por: Lam, Maggie, et al.
Publicado: (2020)

Perspectives on precision cut lung slices—powerful tools for investigation of mechanisms and therapeutic targets in lung diseases
por: Lam, Maggie, et al.
Publicado: (2023)

Serelaxin Treatment Reduces Oxidative Stress and Increases Aldehyde Dehydrogenase-2 to Attenuate Nitrate Tolerance
por: Leo, Chen Huei, et al.
Publicado: (2017)

Acute Intravenous Injection of Serelaxin (Recombinant Human Relaxin‐2) Causes Rapid and Sustained Bradykinin‐Mediated Vasorelaxation
por: Leo, Chen Huei, et al.
Publicado: (2014)

Human Urinary Bladder Strip Relaxation by the β-Adrenoceptor Agonist Isoprenaline: Methodological Considerations and Effects of Gender and Age
por: Schneider, Tim, et al.
Publicado: (2011)

Lipopolysaccharide Does Not Alter Small Airway Reactivity in Mouse Lung Slices
por: Donovan, Chantal, et al.
Publicado: (2015)

Involvement of Cyclic Guanosine Monophosphate-Dependent Protein Kinase I in Renal Antifibrotic Effects of Serelaxin
por: Wetzl, Veronika, et al.
Publicado: (2016)

Effects of serelaxin in subgroups of patients with acute heart failure: results from RELAX-AHF
por: Metra, Marco, et al.
Publicado: (2013)

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways
por: Miner, Kent, et al.
Publicado: (2019)

Effects of serelaxin in acute heart failure patients with renal impairment: results from RELAX-AHF
por: Liu, Licette C. Y., et al.
Publicado: (2016)

Serelaxin in addition to standard therapy in acute heart failure: rationale and design of the RELAX‐AHF‐2 study
por: Teerlink, John R., et al.
Publicado: (2017)

Relaxant Action of Diclofenac Sodium on Mouse Airway Smooth Muscle
por: Chen, Chunfa, et al.
Publicado: (2019)

Chemically Homogenous Compounds with Antagonistic Properties at All α(1)-Adrenoceptor Subtypes but not β(1)-Adrenoceptor Attenuate Adrenaline-Induced Arrhythmia in Rats
por: Pytka, Karolina, et al.
Publicado: (2016)

Chronic Exposure to Cigarette Smoke Affects the Ileum and Colon of Guinea Pigs Differently. Relaxin (RLX-2, Serelaxin) Prevents Most Local Damage
por: Traini, Chiara, et al.
Publicado: (2022)

Serelaxin in acute heart failure patients with and without atrial fibrillation: a secondary analysis of the RELAX-AHF trial
por: Filippatos, Gerasimos, et al.
Publicado: (2017)

Solving the Riddle: Targeting the Imbalance of Sphingolipids in Asthma to Oppose Airway Hyperresponsiveness
por: Lam, Maggie, et al.
Publicado: (2020)

Airway Relaxation Effects of Water-Soluble Sclerotial Extract From Lignosus rhinocerotis
por: Lee, Mei Kee, et al.
Publicado: (2018)

Serelaxin in acute heart failure patients with preserved left ventricular ejection fraction: results from the RELAX-AHF trial
por: Filippatos, Gerasimos, et al.
Publicado: (2014)

Differences in the renal antifibrotic signaling of serelaxin and zaprinast
por: Wetzl, Veronika, et al.
Publicado: (2015)

Differential Effects of Allergen Challenge on Large and Small Airway Reactivity in Mice
por: Donovan, Chantal, et al.
Publicado: (2013)

Can [(125)I]-Iodocyanopindolol Label β(3)-Adrenoceptors in Rat Urinary Bladder?
por: Schneider, Tim, et al.
Publicado: (2010)

β2-Adrenoceptors and GRK2 as Potential Biomarkers in Patients With Chronic Pulmonary Regurgitation
por: Rodriguez-Serrano, María, et al.
Publicado: (2019)

PPARγ Ligands Regulate Noncontractile and Contractile Functions of Airway Smooth Muscle: Implications for Asthma Therapy
por: Donovan, Chantal, et al.
Publicado: (2012)

Editorial: Novel Therapeutic Targets and Emerging Treatments for Fibrosis
por: Samuel, Chrishan S., et al.
Publicado: (2017)

Effect of pre-contraction on β-adrenoceptor-mediated relaxation of rat urinary bladder
por: Michel, Martin Christian, et al.
Publicado: (2009)

Bronchodilator Response Assessment of the Small Airways Obstructive Pattern
por: Bokov, Plamen, et al.
Publicado: (2017)

One stone two birds: anti-inflammatory bronchodilators as a potential pharmacological strategy for COVID-19
por: Yu, Yuanyuan, et al.
Publicado: (2023)

Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation
por: Kashyap, Mahendra, et al.
Publicado: (2015)

Inhibition of prejunctional parasympathetic pathways by β(3)-adrenoceptor agonists in the isolated pig detrusor: comparison with human detrusor studies
por: D’Agostino, Gianluigi, et al.
Publicado: (2023)

Assessment of Airway Bronchodilation by Spirometry Compared to Airway Obstruction in Young Children with Asthma
por: Vilozni, Daphna, et al.
Publicado: (2016)

Serelaxin treatment reverses vascular dysfunction and left ventricular hypertrophy in a mouse model of Type 1 diabetes
por: Ng, Hooi Hooi, et al.
Publicado: (2017)

Airway wall thickness is increased in COPD patients with bronchodilator responsiveness
por: Kim, Victor, et al.
Publicado: (2014)

Effects of sitagliptin on ß-adrenoceptor mediated relaxation in streptozotocin-diabetic rat aorta
por: MÜDERRİSOĞLU, Ayhanım Elif, et al.
Publicado: (2021)

Decoupling Oxygen Tension From Retinal Vascularization as a New Perspective for Management of Retinopathy of Prematurity. New Opportunities From β-adrenoceptors
por: Filippi, Luca, et al.
Publicado: (2022)

Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis
por: Bennett, Robert G, et al.
Publicado: (2017)

Serelaxin improves cardiac and renal function in DOCA-salt hypertensive rats
por: Wang, Dong, et al.
Publicado: (2017)

Serelaxin Alleviates Fibrosis in Thyroid-Associated Ophthalmopathy via the Notch Pathway
por: Sun, Anqi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2f0f489v8jhhkhkdvhss7l6d03