Cargando…

Synthesis and biological evaluation of matrine derivatives containing benzo-α-pyrone structure as potent anti-lung cancer agents

Matrine, an active component of root extracts from Sophora flavescens Ait, is the main chemical ingredient of Fufang Kushen injection which was approved by Chinese FDA (CFDA) in 1995 as an anticancer drug to treat non-small cell lung cancer and liver cancer in combination with other anticancer drugs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Lichuan, Wang, Guizhen, Liu, Shuaibing, Wei, Jinrui, Zhang, Sen, Li, Ming, Zhou, Guangbiao, Wang, Lisheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081519/ https://www.ncbi.nlm.nih.gov/pubmed/27786281 http://dx.doi.org/10.1038/srep35918

Ejemplares similares

Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2
por: Wu, Lichuan, et al.
Publicado: (2016)

Design, Synthesis, Molecular Docking, and Tumor Resistance Reversal Activity Evaluation of Matrine Derivative with Thiophene Structure
por: Wei, Jinrui, et al.
Publicado: (2021)

Biosynthesis of α-pyrones
por: Schäberle, Till F
Publicado: (2016)

Natural Dibenzo-α-Pyrones and Their Bioactivities
por: Mao, Ziling, et al.
Publicado: (2014)

Synthesis and biological evaluation of novel tricyclic matrinic derivatives as potential anti-filovirus agents
por: Zhang, Xin, et al.
Publicado: (2018)

Design, Synthesis and Various Bioactivity of Acylhydrazone-Containing Matrine Analogues
por: Ni, Wanjun, et al.
Publicado: (2023)

Natural Dibenzo-α-Pyrones: Friends or Foes?
por: Aichinger, Georg
Publicado: (2021)

Antimalarial 5,6-Dihydro-α-pyrones from Cryptocarya rigidifolia: Related Bicyclic Tetrahydro-α-Pyrones Are Artifacts1
por: Liu, Yixi, et al.
Publicado: (2015)

Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones
por: Tsukada, Kento, et al.
Publicado: (2020)

Fungal naphtho-γ-pyrones: Potent antibiotics for drug-resistant microbial pathogens
por: He, Yan, et al.
Publicado: (2016)

Synthesis of a Temperature-Sensitive Matrine-Imprinted Polymer and Its Potential Application for the Selective Extraction of Matrine from Radix Sophorae Tonkinensis
por: Jiang, Minjie, et al.
Publicado: (2015)

Synthesis and biological evaluation of tricyclic matrinic derivatives as a class of novel anti-HCV agents
por: Tang, Sheng, et al.
Publicado: (2017)

Two New Bioactive α-Pyrones from Hypericum japonicum
por: Hu, Linzhen, et al.
Publicado: (2016)

Synthesis of a series of benzothiazole amide derivatives and their biological evaluation as potent hemostatic agents
por: Nong, Wenqian, et al.
Publicado: (2018)

Recent Advances in the Synthesis of 2-Pyrones
por: Lee, Jong Seok
Publicado: (2015)

Pharmacokinetic Study of 14-(3-Methylbenzyl)matrine and 14-(4-Methylbenzyl)matrine in Rat Plasma Using Liquid Chromatography-Tandem Mass Spectrometry
por: Jiang, Minjie, et al.
Publicado: (2015)

Syntheses of α-Pyrones Using Gold-Catalyzed Coupling Reactions
por: Luo, Tuoping, et al.
Publicado: (2011)

In vitro reconstitution of α-pyrone ring formation in myxopyronin biosynthesis
por: Sucipto, H., et al.
Publicado: (2015)

Synthesis and Evaluation of 11-Butyl Matrine Derivatives as Potential Anti-Virus Agents
por: Ni, Wanjun, et al.
Publicado: (2022)

Synthesis, Characterization and Activity Evaluation of Matrinic Acid Derivatives as Potential Antiproliferative Agents
por: Chao, Fan, et al.
Publicado: (2013)

Synthesis, characterization and in vitro biological evaluation of two matrine derivatives
por: Cheng, Xingan, et al.
Publicado: (2018)

Novel Matrine Derivatives as Potential Larvicidal Agents against Aedes albopictus: Synthesis, Biological Evaluation, and Mechanistic Analysis
por: Ang, Song, et al.
Publicado: (2023)

Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives
por: Li, Jinlei, et al.
Publicado: (2023)

Trichoderma asperellum Secreted 6-Pentyl-α-Pyrone to Control Magnaporthiopsis maydis, the Maize Late Wilt Disease Agent
por: Degani, Ofir, et al.
Publicado: (2021)

Atom-Economic Synthesis of 4-Pyrones from Diynones and Water
por: Xu, Yan-Li, et al.
Publicado: (2017)

Tetraketide α-pyrone reductases in sporopollenin synthesis pathway in Gerbera hybrida: diversification of the minor function
por: Zhu, Lingping, et al.
Publicado: (2021)

Evolution and Biological Evaluation of Matrinic Derivatives with Amantadine Fragments As New Anti-Influenza Virus Agents
por: Niu, Tianyu, et al.
Publicado: (2019)

Nocapyrones: α- and γ-Pyrones from a Marine-Derived Nocardiopsis sp.
por: Kim, Youngju, et al.
Publicado: (2014)

Production of 6-pentyl-α-pyrone by trichoderma harzianum in solid-state fermentation
por: de Souza Ramos, Aline, et al.
Publicado: (2008)

New α-pyrones from an endophytic fungus, Hypoxylon investiens J2
por: Yuan, Chao, et al.
Publicado: (2019)

Synthesis and Biological Evaluation of Novel Phosphatidylcholine Analogues Containing Monoterpene Acids as Potent Antiproliferative Agents
por: Gliszczyńska, Anna, et al.
Publicado: (2016)

Assessment on facile Diels–Alder approach of α-pyrone and terpenoquinone for the expedient synthesis of various natural scaffolds
por: Rammohan, Aluru, et al.
Publicado: (2022)

Synthesis of γ-pyrones via decarboxylative condensation of β-ketoacids
por: Merad, Jérémy, et al.
Publicado: (2016)

Divergent Synthesis of Pyrone Diterpenes via Radical Cross Coupling
por: Merchant, Rohan R., et al.
Publicado: (2018)

Bis-naphtho-γ-pyrones from Fungi and Their Bioactivities
por: Lu, Shiqiong, et al.
Publicado: (2014)

Research Advances on Matrine
por: Sun, Xiao-Ying, et al.
Publicado: (2022)

α-Pyrone Derivatives from a Streptomyces Strain Resensitize Tamoxifen Resistance in Breast Cancer Cells
por: Yang, Rui-Min, et al.
Publicado: (2017)

Induction of Apoptosis by Matrine Derivative ZS17 in Human Hepatocellular Carcinoma BEL-7402 and HepG2 Cells through ROS-JNK-P53 Signalling Pathway Activation
por: Wang, Xiang, et al.
Publicado: (2022)

Gombapyrones E and F, New α-Pyrone Polyenes Produced by Streptomyces sp. KMC-002
por: Park, Hyun Bong, et al.
Publicado: (2011)

Subcellular Localization of Matrin 3 Containing Mutations Associated with ALS and Distal Myopathy
por: Gallego-Iradi, M. Carolina, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_reak7fl7pkkc9vmij6k85u4o91