RSK1 protects P-glycoprotein/ABCB1 against ubiquitin–proteasomal degradation by downregulating the ubiquitin-conjugating enzyme E2 R1

P-glycoprotein (P-gp) is a critical determinant of multidrug resistance in cancer. We previously reported that MAPK inhibition downregulates P-gp expression and that P-gp undergoes ubiquitin–proteasomal degradation regulated by UBE2R1 and SCF(Fbx15). Here, we investigated the crosstalk between MAPK...

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Detalles Bibliográficos
Autores principales: Katayama, Kazuhiro, Fujiwara, Chiaki, Noguchi, Kohji, Sugimoto, Yoshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081560/
https://www.ncbi.nlm.nih.gov/pubmed/27786305
http://dx.doi.org/10.1038/srep36134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081560/
https://www.ncbi.nlm.nih.gov/pubmed/27786305
http://dx.doi.org/10.1038/srep36134

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