Dose-Dependent Regulation of Alternative Splicing by MBNL Proteins Reveals Biomarkers for Myotonic Dystrophy

Alternative splicing is a regulated process that results in expression of specific mRNA and protein isoforms. Alternative splicing factors determine the relative abundance of each isoform. Here we focus on MBNL1, a splicing factor misregulated in the disease myotonic dystrophy. By altering the conce...

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Detalles Bibliográficos
Autores principales: Wagner, Stacey D., Struck, Adam J., Gupta, Riti, Farnsworth, Dylan R., Mahady, Amy E., Eichinger, Katy, Thornton, Charles A., Wang, Eric T., Berglund, J. Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082313/
https://www.ncbi.nlm.nih.gov/pubmed/27681373
http://dx.doi.org/10.1371/journal.pgen.1006316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082313/
https://www.ncbi.nlm.nih.gov/pubmed/27681373
http://dx.doi.org/10.1371/journal.pgen.1006316

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