Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL‐1β/IL‐1R1/MyD88/NF‐κB pathway

Interleukin (IL)‐1β plays an important role in the pathogenesis of idiopathic pulmonary fibrosis. The production of IL‐1β is dependent upon caspase‐1‐containing multiprotein complexes called inflammasomes and IL‐1R1/MyD88/NF‐κB pathway. In this study, we explored whether a potential anti‐fibrotic ag...

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Detalles Bibliográficos
Autores principales: Song, Cheng, He, Lujuan, Zhang, Jin, Ma, Hong, Yuan, Xiangning, Hu, Gaoyun, Tao, Lijian, Zhang, Jian, Meng, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082399/
https://www.ncbi.nlm.nih.gov/pubmed/27306439
http://dx.doi.org/10.1111/jcmm.12898

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082399/
https://www.ncbi.nlm.nih.gov/pubmed/27306439
http://dx.doi.org/10.1111/jcmm.12898

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