The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts

Accumulation of somatic changes, due to environmental and endogenous lesions, in the human genome is associated with aging and cancer. Understanding the impacts of these processes on mutagenesis is fundamental to understanding the etiology, and improving the prognosis and prevention of cancers and o...

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Detalles Bibliográficos
Autores principales: Saini, Natalie, Roberts, Steven A., Klimczak, Leszek J., Chan, Kin, Grimm, Sara A., Dai, Shuangshuang, Fargo, David C., Boyer, Jayne C., Kaufmann, William K., Taylor, Jack A., Lee, Eunjung, Cortes-Ciriano, Isidro, Park, Peter J., Schurman, Shepherd H., Malc, Ewa P., Mieczkowski, Piotr A., Gordenin, Dmitry A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082821/
https://www.ncbi.nlm.nih.gov/pubmed/27788131
http://dx.doi.org/10.1371/journal.pgen.1006385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082821/
https://www.ncbi.nlm.nih.gov/pubmed/27788131
http://dx.doi.org/10.1371/journal.pgen.1006385

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