Humanizing the Protease-Activated Receptor (PAR) Expression Profile in Mouse Platelets by Knocking PAR1 into the Par3 Locus Reveals PAR1 Expression Is Not Tolerated in Mouse Platelets

Anti-platelet drugs are the mainstay of pharmacotherapy for heart attack and stroke prevention, yet improvements are continually sought. Thrombin is the most potent activator of platelets and targeting platelet thrombin receptors (protease-activated receptors; PARs) is an emerging anti-thrombotic ap...

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Detalles Bibliográficos
Autores principales: French, Shauna L., Paramitha, Antonia C., Moon, Mitchell J., Dickins, Ross A., Hamilton, Justin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082849/
https://www.ncbi.nlm.nih.gov/pubmed/27788223
http://dx.doi.org/10.1371/journal.pone.0165565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082849/
https://www.ncbi.nlm.nih.gov/pubmed/27788223
http://dx.doi.org/10.1371/journal.pone.0165565

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