Exploring the Lean Phenotype of Glutathione-Depleted Mice: Thiol, Amino Acid and Fatty Acid Profiles

BACKGROUND: Although reduced glutathione (rGSH) is decreased in obese mice and humans, block of GSH synthesis by buthionine sulfoximine (BSO) results in a lean, insulin-sensitive phenotype. Data is lacking about the effect of BSO on GSH precursors, cysteine and glutamate. Plasma total cysteine (tCys...

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Detalles Bibliográficos
Autores principales: Elshorbagy, Amany K., Jernerén, Fredrik, Scudamore, Cheryl L., McMurray, Fiona, Cater, Heather, Hough, Tertius, Cox, Roger, Refsum, Helga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082875/
https://www.ncbi.nlm.nih.gov/pubmed/27788147
http://dx.doi.org/10.1371/journal.pone.0163214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082875/
https://www.ncbi.nlm.nih.gov/pubmed/27788147
http://dx.doi.org/10.1371/journal.pone.0163214

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