Cargando…

Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL/6 Mice

The neurotoxicity of paraquat dichloride (PQ) was assessed in two inbred strains of 9- or 16-week old male C57BL/6 mice housed in two different laboratories and compared to the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PQ was administered by intraperitoneal injections; either o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Smeyne, Richard Jay, Breckenridge, Charles B., Beck, Melissa, Jiao, Yun, Butt, Mark T., Wolf, Jeffrey C., Zadory, Dan, Minnema, Daniel J., Sturgess, Nicholas C., Travis, Kim Z., Cook, Andrew R., Smith, Lewis L., Botham, Philip A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082881/ https://www.ncbi.nlm.nih.gov/pubmed/27788145 http://dx.doi.org/10.1371/journal.pone.0164094

Ejemplares similares

Genetic Dissection of Strain Dependent Paraquat-induced Neurodegeneration in the Substantia Nigra Pars Compacta
por: Jiao, Yun, et al.
Publicado: (2012)

Synuclein Proteins in MPTP-Induced Death of Substantia Nigra Pars Compacta Dopaminergic Neurons
por: Goloborshcheva, Valeria V., et al.
Publicado: (2022)

Non-linear developmental trajectory of electrical phenotype in rat substantia nigra pars compacta dopaminergic neurons
por: Dufour, Martial A, et al.
Publicado: (2014)

The Role of the Substantia Nigra Pars Compacta in Regulating Sleep Patterns in Rats
por: Lima, Marcelo M.S., et al.
Publicado: (2007)

Co-Expression of Nogo-A in Dopaminergic Neurons of the Human Substantia Nigra Pars Compacta Is Reduced in Parkinson’s Disease
por: Eyer, Gian-Carlo, et al.
Publicado: (2021)

The h-Current in the Substantia Nigra pars Compacta Neurons: A Re-examination
por: Gambardella, Cristina, et al.
Publicado: (2012)

Nicotine impact on rat substantia nigra compacta
por: Elgayar, Sanaa A M, et al.
Publicado: (2021)

Transient Activation of GABA(B) Receptors Suppresses SK Channel Currents in Substantia Nigra Pars Compacta Dopaminergic Neurons
por: Estep, Chad M., et al.
Publicado: (2016)

Evidence That Substantia Nigra Pars Compacta Dopaminergic Neurons Are Selectively Vulnerable to Oxidative Stress Because They Are Highly Metabolically Active
por: Ni, Anjie, et al.
Publicado: (2022)

nNOS-Expressing Neurons in the Ventral Tegmental Area and Substantia Nigra Pars Compacta
por: Paul, Eleanor J., et al.
Publicado: (2018)

Downregulation of thioredoxin reductase 1 expression in the substantia nigra pars compacta of Parkinson's disease mice
por: Liu, Zihua, et al.
Publicado: (2013)

Reduced complement of dopaminergic neurons in the substantia nigra pars compacta of mice with a constitutive “low footprint” genetic knockout of alpha-synuclein
por: Goloborshcheva, Valeria V., et al.
Publicado: (2020)

Effect of sex and autism spectrum disorder on oxytocin receptor binding and mRNA expression in the dopaminergic pars compacta of the human substantia nigra
por: Frehner, Sage S., et al.
Publicado: (2022)

Acute Neuroinflammatory Response in the Substantia Nigra Pars Compacta of Rats after a Local Injection of Lipopolysaccharide
por: Flores-Martinez, Yazmin M., et al.
Publicado: (2018)

Reinforcement omission effects in rats with bilateral lesions in the substantia nigra pars compacta and ventral tegmental area
por: Tavares, T.F., et al.
Publicado: (2019)

Influence of energy deficiency on the subcellular processes of Substantia Nigra Pars Compacta cell for understanding Parkinsonian neurodegeneration
por: Muddapu, Vignayanandam Ravindernath, et al.
Publicado: (2021)

Automated Assessment of the Substantia Nigra Pars Compacta in Parkinson’s Disease: A Diffusion Tensor Imaging Study
por: Bergsland, Niels, et al.
Publicado: (2021)

Financial gain‐ and loss‐related BOLD signals in the human ventral tegmental area and substantia nigra pars compacta
por: Limbrick‐Oldfield, Eve H., et al.
Publicado: (2018)

Stress Controllability Modulates Basal Activity of Dopamine Neurons in the Substantia Nigra Compacta
por: Yao, Li, et al.
Publicado: (2021)

Increased iron-deposition in lateral-ventral substantia nigra pars compacta: A promising neuroimaging marker for Parkinson's disease
por: He, Naying, et al.
Publicado: (2020)

Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons
por: Company, Verónica, et al.
Publicado: (2021)

Single-cell analysis of gene expression in the substantia nigra pars compacta of a pesticide-induced mouse model of Parkinson’s disease
por: Khan, Arshad H., et al.
Publicado: (2022)

Acute Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or Paraquat on Core Temperature in C57BL/6J Mice
por: Jiao, Yun, et al.
Publicado: (2015)

Angiotensin type 1 receptor antagonist losartan, reduces MPTP-induced degeneration of dopaminergic neurons in substantia nigra
por: Grammatopoulos, Tom N, et al.
Publicado: (2007)

Beneficial effects of PGC-1α in the substantia nigra of a mouse model of MPTP-induced dopaminergic neurotoxicity
por: Wang, Yingqing, et al.
Publicado: (2019)

The effects of ninjin’yoeito on the electrophysiological properties of dopamine neurons in the ventral tegmental area/substantia nigra pars compacta and medium spiny neurons in the nucleus accumbens
por: Imai, Ryota, et al.
Publicado: (2022)

Repeated Methamphetamine Administration Results in Axon Loss Prior to Somatic Loss of Substantia Nigra Pars Compacta and Locus Coeruleus Neurons in Male but Not Female Mice
por: Pilski, Alexander, et al.
Publicado: (2023)

Mg(2+) block properties of triheteromeric GluN1–GluN2B–GluN2D NMDA receptors on neonatal rat substantia nigra pars compacta dopaminergic neurones
por: Huang, Zhuo, et al.
Publicado: (2014)

Mesencephalic origin of the rostral Substantia nigra pars reticulata
por: Madrigal, M. Pilar, et al.
Publicado: (2015)

Manganese exposure in juvenile C57BL/6 mice increases glial inflammatory responses in the substantia nigra following infection with H1N1 influenza virus
por: Bantle, Collin M., et al.
Publicado: (2021)

S40. MEDIAL SEPTUM ACTIVATION PRODUCES OPPOSITE EFFECTS ON DOPAMINE NEURON ACTIVITY IN THE VENTRAL TEGMENTAL AREA AND SUBSTANTIA NIGRA PARS COMPACTA IN MAM VERSUS NORMAL RATS
por: Bortz, David, et al.
Publicado: (2018)

Metabolic Disturbances in the Striatum and Substantia Nigra in the Onset and Progression of MPTP-Induced Parkinsonism Model
por: Lu, Yi, et al.
Publicado: (2018)

Paraquat Toxicogenetics: Strain-Related Reduction of Tyrosine Hydroxylase Staining in Substantia Nigra in Mice
por: Torres-Rojas, Carolina, et al.
Publicado: (2021)

Activity of the Substantia Nigra Pars Reticulata during Saccade Adaptation
por: Kojima, Yoshiko, et al.
Publicado: (2023)

Dopaminergic Presynaptic Modulation of Nigral Afferents: Its Role in the Generation of Recurrent Bursting in Substantia Nigra Pars Reticulata Neurons
por: de Jesús Aceves, José, et al.
Publicado: (2011)

Activity-dependent regulation of NMDA receptors in substantia nigra dopaminergic neurones
por: Wild, Angela R, et al.
Publicado: (2014)

Dopaminergic Neurodegeneration in the Mouse Is Associated with Decrease of Viscoelasticity of Substantia Nigra Tissue
por: Hain, Elisabeth G., et al.
Publicado: (2016)

Measuring the iron content of dopaminergic neurons in substantia nigra with MRI relaxometry
por: Brammerloh, Malte, et al.
Publicado: (2021)

Ca(V)1.3 L-Type Calcium Channels Increase the Vulnerability of Substantia Nigra Dopaminergic Neurons in MPTP Mouse Model of Parkinson’s Disease
por: Verma, Aditi, et al.
Publicado: (2020)

HOTAIR drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of Parkinson’s disease by elevating NPTX2 via miR-221-3p binding
por: Lang, Yue, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_7d9jdejvkuduemvlbptedfrotr