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Maintenance of Xist Imprinting Depends on Chromatin Condensation State and Rnf12 Dosage in Mice

In female mammals, activation of Xist (X-inactive specific transcript) is essential for establishment of X chromosome inactivation. During early embryonic development in mice, paternal Xist is preferentially expressed whereas maternal Xist (Xm-Xist) is silenced. Unlike autosomal imprinted genes, Xis...

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Detalles Bibliográficos
Autores principales: Fukuda, Atsushi, Mitani, Atsushi, Miyashita, Toshiyuki, Sado, Takashi, Umezawa, Akihiro, Akutsu, Hidenori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082930/
https://www.ncbi.nlm.nih.gov/pubmed/27788132
http://dx.doi.org/10.1371/journal.pgen.1006375