P2Y(1) Receptor Signaling Contributes to High Salt-Induced Priming of the NLRP3 Inflammasome in Retinal Pigment Epithelial Cells

BACKGROUND: Systemic hypertension is a risk factor of age-related macular degeneration (AMD), a chronic inflammatory disease. Acute hypertension is caused by increased extracellular osmolarity after intake of dietary salt (NaCl). We determined in cultured human retinal pigment epithelial (RPE) cells...

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Detalles Bibliográficos
Autores principales: Prager, Philipp, Hollborn, Margrit, Steffen, Anja, Wiedemann, Peter, Kohen, Leon, Bringmann, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082949/
https://www.ncbi.nlm.nih.gov/pubmed/27788256
http://dx.doi.org/10.1371/journal.pone.0165653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082949/
https://www.ncbi.nlm.nih.gov/pubmed/27788256
http://dx.doi.org/10.1371/journal.pone.0165653

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