Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras

The capacity to integrate transgenes into the host cell genome makes retroviral vectors an interesting tool for gene therapy. Although stable insertion resulted in successful correction of several monogenic disorders, it also accounts for insertional mutagenesis, a major setback in otherwise success...

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Detalles Bibliográficos
Autores principales: Vranckx, Lenard S., Demeulemeester, Jonas, Debyser, Zeger, Gijsbers, Rik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082951/
https://www.ncbi.nlm.nih.gov/pubmed/27788138
http://dx.doi.org/10.1371/journal.pone.0164167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082951/
https://www.ncbi.nlm.nih.gov/pubmed/27788138
http://dx.doi.org/10.1371/journal.pone.0164167

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