Modeling disease risk through analysis of physical interactions between genetic variants within chromatin regulatory circuitry

SNPs associated with disease susceptibility often reside in clusters of gene enhancers, or super enhancers. Constituents of these enhancer clusters cooperate to regulate target genes, and often extend beyond the linkage disequilibrium blocks containing GWAS risk SNPs. We identified “outside variants...

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Detalles Bibliográficos
Autores principales: Corradin, Olivia, Cohen, Andrea J., Luppino, Jennifer M., Bayles, Ian M., Schumacher, Fredrick R., Scacheri, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083135/
https://www.ncbi.nlm.nih.gov/pubmed/27643537
http://dx.doi.org/10.1038/ng.3674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083135/
https://www.ncbi.nlm.nih.gov/pubmed/27643537
http://dx.doi.org/10.1038/ng.3674

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