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Modeling disease risk through analysis of physical interactions between genetic variants within chromatin regulatory circuitry
SNPs associated with disease susceptibility often reside in clusters of gene enhancers, or super enhancers. Constituents of these enhancer clusters cooperate to regulate target genes, and often extend beyond the linkage disequilibrium blocks containing GWAS risk SNPs. We identified “outside variants...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083135/ https://www.ncbi.nlm.nih.gov/pubmed/27643537 http://dx.doi.org/10.1038/ng.3674 |