Mitochondrial Dysfunction in the Liver and Antiphospholipid Antibody Production Precede Disease Onset and Respond to Rapamycin in Lupus‐Prone Mice

OBJECTIVE: Antiphospholipid antibodies (aPL) constitute a diagnostic criterion of systemic lupus erythematosus (SLE), and aPL have been functionally linked to liver disease in patients with SLE. Since the mechanistic target of rapamycin (mTOR) is a regulator of oxidative stress, a pathophysiologic p...

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Detalles Bibliográficos
Autores principales: Oaks, Zachary, Winans, Thomas, Caza, Tiffany, Fernandez, David, Liu, Yuxin, Landas, Steve K., Banki, Katalin, Perl, Andras
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Systemic Lupus Erythematosus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083168/
https://www.ncbi.nlm.nih.gov/pubmed/27332042
http://dx.doi.org/10.1002/art.39791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083168/
https://www.ncbi.nlm.nih.gov/pubmed/27332042
http://dx.doi.org/10.1002/art.39791

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