An inducible long noncoding RNA amplifies DNA damage signaling

Long noncoding RNAs (lncRNAs) are prevalent genes with frequently exquisite regulation but mostly unknown functions. Here we demonstrate a role of lncRNAs in guiding organismal DNA damage response. DNA damage activates transcription of DINO (Damage Induced NOncoding) via p53. DINO is required for p5...

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Detalles Bibliográficos
Autores principales: Schmitt, Adam M., Garcia, Julia T., Hung, Tiffany, Flynn, Ryan A., Shen, Ying, Qu, Kun, Payumo, Alexander Y., Peres-da-Silva, Ashwin, Broz, Daniela Kenzelmann, Baum, Rachel, Guo, Shuling, Chen, James K., Attardi, Laura D., Chang, Howard Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083181/
https://www.ncbi.nlm.nih.gov/pubmed/27668660
http://dx.doi.org/10.1038/ng.3673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083181/
https://www.ncbi.nlm.nih.gov/pubmed/27668660
http://dx.doi.org/10.1038/ng.3673

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