The PARP inhibitor ABT-888 potentiates darbazine-induced cell death in carcinoids

Monoagent DNA-alkylating chemotherapies like dacarbazine are among a paucity of medical treatments for advanced carcinoid tumors, but are limited by host toxicity and intrinsic chemoresistance through the base excision repair (BER) pathway via poly (ADP-ribose) polymerase (PARP). Hence, inhibitors o...

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Detalles Bibliográficos
Autores principales: Somnay, Yash, Lubner, Sam, Gill, Harpreet, Matsumura, Jon Blake, Chen, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083201/
https://www.ncbi.nlm.nih.gov/pubmed/27632933
http://dx.doi.org/10.1038/cgt.2016.39

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083201/
https://www.ncbi.nlm.nih.gov/pubmed/27632933
http://dx.doi.org/10.1038/cgt.2016.39

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