MeCP2 and Histone Deacetylases 1 and 2 in Dorsal Striatum Collectively Suppress Repetitive Behaviors

Class I histone deacetylases (HDACs), HDAC1 and HDAC2 often associate together in protein complexes with transcriptional factors such as methyl-CpG-binding protein 2 (MeCP2). Given their high degree of sequence identity, we examined the functional redundancy of HDAC1 and HDAC2 in mature brain. We de...

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Detalles Bibliográficos
Autores principales: Mahgoub, Melissa, Adachi, Megumi, Suzuki, Kanzo, Liu, Xihui, Kavalali, Ege T., Chahrour, Maria H., Monteggia, Lisa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083208/
https://www.ncbi.nlm.nih.gov/pubmed/27668390
http://dx.doi.org/10.1038/nn.4395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083208/
https://www.ncbi.nlm.nih.gov/pubmed/27668390
http://dx.doi.org/10.1038/nn.4395

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