Dabigatran antagonizes growth, cell‐cycle progression, migration, and endothelial tube formation induced by thrombin in breast and glioblastoma cell lines

Thrombin activates its G‐coupled seven transmembrane protease‐activated receptor (PAR‐1) by cleaving the receptor's N‐terminal end. In several human cancers, PAR1 expression and activation correlates with tumor progression and metastatization. This provides compelling evidence for the effective...

Descripción completa

Detalles Bibliográficos
Autores principales: Vianello, Fabrizio, Sambado, Luisa, Goss, Ashley, Fabris, Fabrizio, Prandoni, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083743/
https://www.ncbi.nlm.nih.gov/pubmed/27600331
http://dx.doi.org/10.1002/cam4.857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083743/
https://www.ncbi.nlm.nih.gov/pubmed/27600331
http://dx.doi.org/10.1002/cam4.857

Ejemplares similares