Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients

PURPOSE: Methotrexate administration is associated with frequent adverse neurological events during treatment for childhood acute lymphoblastic leukemia. Here, we present evidence to support the role of common drug interactions and low vitamin B(12) levels in potentiating methotrexate neurotoxicity....

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Detalles Bibliográficos
Autores principales: Forster, Victoria J., van Delft, Frederik W., Baird, Susan F., Mair, Shona, Skinner, Roderick, Halsey, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083755/
https://www.ncbi.nlm.nih.gov/pubmed/27659182
http://dx.doi.org/10.1007/s00280-016-3153-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083755/
https://www.ncbi.nlm.nih.gov/pubmed/27659182
http://dx.doi.org/10.1007/s00280-016-3153-0

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