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Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients
PURPOSE: Methotrexate administration is associated with frequent adverse neurological events during treatment for childhood acute lymphoblastic leukemia. Here, we present evidence to support the role of common drug interactions and low vitamin B(12) levels in potentiating methotrexate neurotoxicity....
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083755/ https://www.ncbi.nlm.nih.gov/pubmed/27659182 http://dx.doi.org/10.1007/s00280-016-3153-0 |