Effect of veliparib (ABT-888) on cardiac repolarization in patients with advanced solid tumors: a randomized, placebo-controlled crossover study

PURPOSE: Veliparib (ABT-888) is an orally bioavailable potent inhibitor of poly(ADP-ribose) polymerase (PARP)-1 and PARP-2. This phase 1 study evaluated the effect of veliparib on corrected QT interval using Fridericia’s formula (QTcF). METHODS: Eligible patients with advanced solid tumors received...

Descripción completa

Detalles Bibliográficos
Autores principales: Munasinghe, Wijith, Stodtmann, Sven, Tolcher, Anthony, Calvo, Emiliano, Gordon, Michael, Jalving, Mathilde, de Vos-Geelen, Judith, Medina, Diane, Bergau, Dennis, Nuthalapati, Silpa, Hoffman, David, Shepherd, Stacie, Xiong, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083757/
https://www.ncbi.nlm.nih.gov/pubmed/27709282
http://dx.doi.org/10.1007/s00280-016-3156-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083757/
https://www.ncbi.nlm.nih.gov/pubmed/27709282
http://dx.doi.org/10.1007/s00280-016-3156-x

Ejemplares similares