Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations

[Image: see text] The CRISPR (clustered regularly interspaced short palindromic repeats)-Cas9 system recently emerged as a transformative genome-editing technology that is innovating basic bioscience and applied medicine and biotechnology. The endonuclease Cas9 associates with a guide RNA to match a...

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Detalles Bibliográficos
Autores principales: Palermo, Giulia, Miao, Yinglong, Walker, Ross C., Jinek, Martin, McCammon, J. Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084073/
https://www.ncbi.nlm.nih.gov/pubmed/27800559
http://dx.doi.org/10.1021/acscentsci.6b00218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084073/
https://www.ncbi.nlm.nih.gov/pubmed/27800559
http://dx.doi.org/10.1021/acscentsci.6b00218

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