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PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy

Mitochondrial fission is essential for the degradation of damaged mitochondria. It is currently unknown how the dynamin-related protein 1 (DRP1)–associated fission machinery is selectively targeted to segregate damaged mitochondria. We show that PTEN-induced putative kinase (PINK1) serves as a pro-f...

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Detalles Bibliográficos
Autores principales:	Pryde, Kenneth R., Smith, Heather L., Chau, Kai-Yin, Schapira, Anthony H.V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084273/ https://www.ncbi.nlm.nih.gov/pubmed/27091447 http://dx.doi.org/10.1083/jcb.201509003

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