Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype

In the degenerative disease Duchenne muscular dystrophy, inflammatory cells enter muscles in response to repetitive muscle damage. Immune factors are required for muscle regeneration, but chronic inflammation creates a profibrotic milieu that exacerbates disease progression. Osteopontin (OPN) is an...

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Detalles Bibliográficos
Autores principales: Capote, Joana, Kramerova, Irina, Martinez, Leonel, Vetrone, Sylvia, Barton, Elisabeth R., Sweeney, H. Lee, Miceli, M. Carrie, Spencer, Melissa J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084275/
https://www.ncbi.nlm.nih.gov/pubmed/27091452
http://dx.doi.org/10.1083/jcb.201510086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084275/
https://www.ncbi.nlm.nih.gov/pubmed/27091452
http://dx.doi.org/10.1083/jcb.201510086

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