Protein misfolding specifies recruitment to cytoplasmic inclusion bodies

Inclusion bodies (IBs) containing aggregated disease-associated proteins and polyubiquitin (poly-Ub) conjugates are universal histopathological features of neurodegenerative diseases. Ub has been proposed to target proteins to IBs for degradation via autophagy, but the mechanisms that govern recruit...

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Detalles Bibliográficos
Autores principales: Bersuker, Kirill, Brandeis, Michael, Kopito, Ron R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084276/
https://www.ncbi.nlm.nih.gov/pubmed/27114501
http://dx.doi.org/10.1083/jcb.201511024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084276/
https://www.ncbi.nlm.nih.gov/pubmed/27114501
http://dx.doi.org/10.1083/jcb.201511024

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