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Epidermal growth factor prevents APOE4 and amyloid-beta-induced cognitive and cerebrovascular deficits in female mice

Cerebrovascular (CV) dysfunction is emerging as a critical component of Alzheimer’s disease (AD), including altered CV coverage. Angiogenic growth factors (AGFs) are key for controlling CV coverage, especially during disease pathology. Therefore, evaluating the effects of AGFs in vivo can provide im...

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Detalles Bibliográficos
Autores principales: Thomas, Riya, Zuchowska, Paulina, Morris, Alan W. J., Marottoli, Felecia M., Sunny, Sangeeta, Deaton, Ryan, Gann, Peter H., Tai, Leon M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084423/
https://www.ncbi.nlm.nih.gov/pubmed/27788676
http://dx.doi.org/10.1186/s40478-016-0387-3