Cargando…

Epidermal growth factor prevents APOE4 and amyloid-beta-induced cognitive and cerebrovascular deficits in female mice

Cerebrovascular (CV) dysfunction is emerging as a critical component of Alzheimer’s disease (AD), including altered CV coverage. Angiogenic growth factors (AGFs) are key for controlling CV coverage, especially during disease pathology. Therefore, evaluating the effects of AGFs in vivo can provide im...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thomas, Riya, Zuchowska, Paulina, Morris, Alan W. J., Marottoli, Felecia M., Sunny, Sangeeta, Deaton, Ryan, Gann, Peter H., Tai, Leon M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084423/ https://www.ncbi.nlm.nih.gov/pubmed/27788676 http://dx.doi.org/10.1186/s40478-016-0387-3

Ejemplares similares

Epidermal growth factor prevents APOE4-induced cognitive and cerebrovascular deficits in female mice
por: Thomas, Riya, et al.
Publicado: (2017)

Epidermal growth factor treatment of female mice that express APOE4 at an age of advanced pathology mitigates behavioral and cerebrovascular dysfunction
por: Zaldua, Steve, et al.
Publicado: (2020)

Peripheral Inflammation, Apolipoprotein E4, and Amyloid-β Interact to Induce Cognitive and Cerebrovascular Dysfunction
por: Marottoli, Felecia M., et al.
Publicado: (2017)

APOE4 Promotes Tonic-Clonic Seizures, an Effect Modified by Familial Alzheimer’s Disease Mutations
por: Lamoureux, Lorissa, et al.
Publicado: (2021)

Systemic Candesartan Treatment Modulates Behavior, Synaptic Protein Levels, and Neuroinflammation in Female Mice That Express Human APOE4
por: Scheinman, Sarah B., et al.
Publicado: (2021)

LPC-DHA/EPA-Enriched Diets Increase Brain DHA and Modulate Behavior in Mice That Express Human APOE4
por: Scheinman, Sarah B., et al.
Publicado: (2021)

Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy
por: Xiong, Monica, et al.
Publicado: (2023)

Endothelial Cell APOE3 Regulates Neurovascular, Neuronal, and Behavioral Function
por: Marottoli, Felecia M., et al.
Publicado: (2023)

Learning deficit in cognitively normal APOE ε4 carriers with LOW β‐amyloid
por: Lim, Yen Ying, et al.
Publicado: (2021)

The Cerebrovascular Basement Membrane: Role in the Clearance of β-amyloid and Cerebral Amyloid Angiopathy
por: Morris, Alan W. J., et al.
Publicado: (2014)

APOE and Alzheimer’s Disease: Neuroimaging of Metabolic and Cerebrovascular Dysfunction
por: Brandon, Jason A., et al.
Publicado: (2018)

Effects of apoE Deficiency and Occlusal Disharmony on Amyloid-Beta Production and Spatial Memory in Rats
por: Ekuni, Daisuke, et al.
Publicado: (2013)

A cautionary tale of an emergency cerebrovascular procedure in the COVID-19 era
por: Abdou, Hossam, et al.
Publicado: (2020)

Brain ApoA-I, ApoJ and ApoE Immunodetection in Cerebral Amyloid Angiopathy
por: Camacho, Jessica, et al.
Publicado: (2019)

APOE-amyloid interaction: Therapeutic targets
por: Wisniewski, Thomas, et al.
Publicado: (2020)

The role of APOE-ɛ4 and beta amyloid in the differential rate of recovery from ECT: a review
por: Sutton, T A, et al.
Publicado: (2015)

Independent and Interactive Influences of the APOE Genotype and Beta-Amyloid Burden on Cognitive Function in Mild Cognitive Impairment
por: Seo, Eun Hyun, et al.
Publicado: (2016)

Determining the Role of ApoE4 in Age-Related Cerebrovascular Decline
por: Foley, Kate, et al.
Publicado: (2020)

Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease
por: Ibanez, Laura, et al.
Publicado: (2020)

Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice
por: Ilievski, Vladimir, et al.
Publicado: (2018)

Autocrine Effects of Brain Endothelial Cell-Produced Human Apolipoprotein E on Metabolism and Inflammation in vitro
por: Marottoli, Felecia M., et al.
Publicado: (2021)

An association of CSF apolipoprotein E glycosylation and amyloid-beta 42 in individuals who carry the APOE4 allele
por: Meuret, Cristiana J., et al.
Publicado: (2023)

An Aged Canid with Behavioral Deficits Exhibits Blood and Cerebrospinal Fluid Amyloid Beta Oligomers
por: Rusbridge, Clare, et al.
Publicado: (2018)

APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice
por: Area-Gomez, Estela, et al.
Publicado: (2020)

Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice
por: de Retana, Sofía Fernández, et al.
Publicado: (2019)

Higher Level of Mismatch in APOE ε4 Carriers for Amyloid-Beta Peptide Alzheimer’s Disease Biomarkers in Cerebrospinal Fluid
por: Vogelgsang, Jonathan, et al.
Publicado: (2019)

APOE ε4 gene dose effect on imaging and blood biomarkers of neuroinflammation and beta-amyloid in cognitively unimpaired elderly
por: Snellman, Anniina, et al.
Publicado: (2023)

FLZ Alleviates the Memory Deficits in Transgenic Mouse Model of Alzheimer’s Disease via Decreasing Beta-Amyloid Production and Tau Hyperphosphorylation
por: Bao, Xiu-Qi, et al.
Publicado: (2013)

Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid
por: Maki, Takakuni, et al.
Publicado: (2014)

Cerebrovascular Reactivity Across the Entire Brain in Cerebral Amyloid Angiopathy
por: Beaudin, Andrew E., et al.
Publicado: (2022)

Cerebrovascular stiffness and flow dynamics in the presence of amyloid and tau biomarkers
por: Rivera‐Rivera, Leonardo A., et al.
Publicado: (2021)

ApoE Alzheimer’s Disease Aβ-amyloid plaque morphology varies according to APOE isotype
por: Caesar, Ina, et al.
Publicado: (2023)

Cerebrovascular Changes and Neurodegeneration Related to Hyperlipidemia: Characteristics of the Human ApoB-100 Transgenic Mice
por: Tóth, Melinda E., et al.
Publicado: (2020)

LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4
por: Oue, Hiroshi, et al.
Publicado: (2023)

ApoE facilitates the microglial response to amyloid plaque pathology
por: Ulrich, Jason D., et al.
Publicado: (2018)

The Clustering of mApoE Anti-Amyloidogenic Peptide on Nanoparticle Surface Does Not Alter Its Performance in Controlling Beta-Amyloid Aggregation
por: Corti, Roberta, et al.
Publicado: (2020)

In Silico Analysis of the Antagonist Effect of Enoxaparin on the ApoE4–Amyloid-Beta (Aβ) Complex at Different pH Conditions
por: Aguilar-Pineda, Jorge Alberto, et al.
Publicado: (2022)

Peripheral metabolism of lipoprotein-amyloid beta as a risk factor for Alzheimer’s disease: potential interactive effects of APOE genotype with dietary fats
por: D’Alonzo, Zachary J., et al.
Publicado: (2023)

A Humanin Derivative Reduces Amyloid Beta Accumulation and Ameliorates Memory Deficit in Triple Transgenic Mice
por: Niikura, Takako, et al.
Publicado: (2011)

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease
por: Pickett, Eleanor K., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_n65gpj34651pq1dlnvqlvj3t0o