Cargando…

WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway

The stability of β‐catenin is very important for canonical Wnt signaling. A protein complex including Axin/APC/GSK3β phosphorylates β‐catenin to be degraded by ubiquitination with β‐TrCP. In the recent study, we isolated WDR26, a protein that binds to Axin. Here, we found that WDR26 is a negative re...

Descripción completa

Detalles Bibliográficos
Autores principales: Goto, Toshiyasu, Matsuzawa, Junhei, Iemura, Shun‐ichiro, Natsume, Tohru, Shibuya, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084729/
https://www.ncbi.nlm.nih.gov/pubmed/27098453
http://dx.doi.org/10.1002/1873-3468.12180