WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway

The stability of β‐catenin is very important for canonical Wnt signaling. A protein complex including Axin/APC/GSK3β phosphorylates β‐catenin to be degraded by ubiquitination with β‐TrCP. In the recent study, we isolated WDR26, a protein that binds to Axin. Here, we found that WDR26 is a negative re...

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Detalles Bibliográficos
Autores principales: Goto, Toshiyasu, Matsuzawa, Junhei, Iemura, Shun‐ichiro, Natsume, Tohru, Shibuya, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084729/
https://www.ncbi.nlm.nih.gov/pubmed/27098453
http://dx.doi.org/10.1002/1873-3468.12180
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author Goto, Toshiyasu
Matsuzawa, Junhei
Iemura, Shun‐ichiro
Natsume, Tohru
Shibuya, Hiroshi
author_facet Goto, Toshiyasu
Matsuzawa, Junhei
Iemura, Shun‐ichiro
Natsume, Tohru
Shibuya, Hiroshi
author_sort Goto, Toshiyasu
collection PubMed
description The stability of β‐catenin is very important for canonical Wnt signaling. A protein complex including Axin/APC/GSK3β phosphorylates β‐catenin to be degraded by ubiquitination with β‐TrCP. In the recent study, we isolated WDR26, a protein that binds to Axin. Here, we found that WDR26 is a negative regulator of the canonical Wnt signaling pathway, and that WDR26 affected β‐catenin levels. In addition, WDR26/Axin binding is involved in the ubiquitination of β‐catenin. These results suggest that WDR26 plays a negative role in β‐catenin degradation in the Wnt signaling pathway.
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spelling pubmed-50847292016-11-09 WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway Goto, Toshiyasu Matsuzawa, Junhei Iemura, Shun‐ichiro Natsume, Tohru Shibuya, Hiroshi FEBS Lett Research Letters The stability of β‐catenin is very important for canonical Wnt signaling. A protein complex including Axin/APC/GSK3β phosphorylates β‐catenin to be degraded by ubiquitination with β‐TrCP. In the recent study, we isolated WDR26, a protein that binds to Axin. Here, we found that WDR26 is a negative regulator of the canonical Wnt signaling pathway, and that WDR26 affected β‐catenin levels. In addition, WDR26/Axin binding is involved in the ubiquitination of β‐catenin. These results suggest that WDR26 plays a negative role in β‐catenin degradation in the Wnt signaling pathway. John Wiley and Sons Inc. 2016-05-03 2016-05 /pmc/articles/PMC5084729/ /pubmed/27098453 http://dx.doi.org/10.1002/1873-3468.12180 Text en © 2016 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Letters
Goto, Toshiyasu
Matsuzawa, Junhei
Iemura, Shun‐ichiro
Natsume, Tohru
Shibuya, Hiroshi
WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway
title WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway
title_full WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway
title_fullStr WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway
title_full_unstemmed WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway
title_short WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway
title_sort wdr26 is a new partner of axin1 in the canonical wnt signaling pathway
topic Research Letters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084729/
https://www.ncbi.nlm.nih.gov/pubmed/27098453
http://dx.doi.org/10.1002/1873-3468.12180
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