AMPK Activation Prevents and Reverses Drug-Induced Mitochondrial and Hepatocyte Injury by Promoting Mitochondrial Fusion and Function

Mitochondrial damage is the major factor underlying drug-induced liver disease but whether conditions that thwart mitochondrial injury can prevent or reverse drug-induced liver damage is unclear. A key molecule regulating mitochondria quality control is AMP activated kinase (AMPK). When activated, A...

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Detalles Bibliográficos
Autores principales: Kang, Sun Woo Sophie, Haydar, Ghada, Taniane, Caitlin, Farrell, Geoffrey, Arias, Irwin M., Lippincott-Schwartz, Jennifer, Fu, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085033/
https://www.ncbi.nlm.nih.gov/pubmed/27792760
http://dx.doi.org/10.1371/journal.pone.0165638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085033/
https://www.ncbi.nlm.nih.gov/pubmed/27792760
http://dx.doi.org/10.1371/journal.pone.0165638

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