Hydrogen Bond Dynamic Propensity Studies for Protein Binding and Drug Design

We study the dynamic propensity of the backbone hydrogen bonds of the protein MDM2 (the natural regulator of the tumor suppressor p53) in order to determine its binding properties. This approach is fostered by the observation that certain backbone hydrogen bonds at the p53-binding site exhibit a dyn...

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Detalles Bibliográficos
Autores principales: Menéndez, Cintia A., Accordino, Sebastián R., Gerbino, Darío C., Appignanesi, Gustavo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085089/
https://www.ncbi.nlm.nih.gov/pubmed/27792778
http://dx.doi.org/10.1371/journal.pone.0165767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085089/
https://www.ncbi.nlm.nih.gov/pubmed/27792778
http://dx.doi.org/10.1371/journal.pone.0165767

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