Metabolic reprogramming of glioblastoma cells by L-asparaginase sensitizes for apoptosis in vitro and in vivo

Cancer cells display a variety of global metabolic changes, which aside from the glycolytic pathway largely involve amino acid metabolism. To ensure aggressive growth, tumor cells highly depend on amino acids, most notably due to their pivotal need of protein synthesis. In this study, we assessed th...

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Detalles Bibliográficos
Autores principales: Karpel-Massler, Georg, Ramani, Doruntina, Shu, Chang, Halatsch, Marc-Eric, Westhoff, Mike-Andrew, Bruce, Jeffrey N., Canoll, Peter, Siegelin, Markus D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085099/
https://www.ncbi.nlm.nih.gov/pubmed/27172899
http://dx.doi.org/10.18632/oncotarget.9257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085099/
https://www.ncbi.nlm.nih.gov/pubmed/27172899
http://dx.doi.org/10.18632/oncotarget.9257

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