Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic

Cancer-selective drug delivery is an important concept in improving treatment while minimizing off-site toxicities, and sigma-2 receptors, which are overexpressed in solid tumors, represent attractive pharmacologic targets. Select sigma-2 ligands have been shown to be rapidly internalized selectivel...

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Detalles Bibliográficos
Autores principales: Ohman, Kerri A., Hashim, Yassar M., Vangveravong, Suwanna, Nywening, Timothy M., Cullinan, Darren R., Goedegebuure, S. Peter, Liu, Jingxia, Van Tine, Brian A., Tiriac, Herve, Tuveson, David A., DeNardo, David G., Spitzer, Dirk, Mach, Robert H., Hawkins, William G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085100/
https://www.ncbi.nlm.nih.gov/pubmed/27244881
http://dx.doi.org/10.18632/oncotarget.9551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085100/
https://www.ncbi.nlm.nih.gov/pubmed/27244881
http://dx.doi.org/10.18632/oncotarget.9551

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