Quinazoline derivative QPB-15e stabilizes the c-myc promoter G-quadruplex and inhibits tumor growth in vivo

The ribozyme-sensitive element NHE-III1 in the P1 promoter region of the important proto-oncogene c-myc contains many guanine (G)-rich sequences. Induction and stabilization of the G-quadruplex formed by NHE-III1 can downregulate c-myc expression. In the present study, we found that QPB-15e, a quina...

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Detalles Bibliográficos
Autores principales: Li, Zeng, Liu, Chen, Huang, Cheng, Meng, Xiaoming, Zhang, Lei, He, Jinhui, Li, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085154/
https://www.ncbi.nlm.nih.gov/pubmed/27144522
http://dx.doi.org/10.18632/oncotarget.9088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085154/
https://www.ncbi.nlm.nih.gov/pubmed/27144522
http://dx.doi.org/10.18632/oncotarget.9088

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