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Identification of cytotoxic agents disrupting synovial sarcoma oncoprotein interactions by proximity ligation assay
Conventional cytotoxic therapies for synovial sarcoma provide limited benefit. Drugs specifically targeting the product of its driver translocation are currently unavailable, in part because the SS18-SSX oncoprotein functions via aberrant interactions within multiprotein complexes. Proximity ligatio...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085163/ https://www.ncbi.nlm.nih.gov/pubmed/27120803 http://dx.doi.org/10.18632/oncotarget.8882 |