Identification of cytotoxic agents disrupting synovial sarcoma oncoprotein interactions by proximity ligation assay

Conventional cytotoxic therapies for synovial sarcoma provide limited benefit. Drugs specifically targeting the product of its driver translocation are currently unavailable, in part because the SS18-SSX oncoprotein functions via aberrant interactions within multiprotein complexes. Proximity ligatio...

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Detalles Bibliográficos
Autores principales: Laporte, Aimée N., Ji, Jennifer X., Ma, Limin, Nielsen, Torsten O., Brodin, Bertha A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085163/
https://www.ncbi.nlm.nih.gov/pubmed/27120803
http://dx.doi.org/10.18632/oncotarget.8882

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