Multiplicity of acquired cross-resistance in paclitaxel-resistant cancer cells is associated with feedback control of TUBB3 via FOXO3a-mediated ABCB1 regulation

Acquired drug resistance is a primary obstacle for effective cancer therapy. The correlation of point mutations in class III β-tubulin (TUBB3) and the prominent overexpression of ATP-binding cassette P-glycoprotein (ABCB1), a multidrug resistance gene, have been protruding mechanisms of resistance t...

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Detalles Bibliográficos
Autores principales: Aldonza, Mark Borris D., Hong, Ji-Young, Alinsug, Malona V., Song, Jayoung, Lee, Sang Kook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085164/
https://www.ncbi.nlm.nih.gov/pubmed/27284014
http://dx.doi.org/10.18632/oncotarget.9118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085164/
https://www.ncbi.nlm.nih.gov/pubmed/27284014
http://dx.doi.org/10.18632/oncotarget.9118

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